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MBNL1 抗体 (C-Term)

Name: MBNL1 抗体 (C-Term)
SKU: ABIN1881533
Availability: OutOfStock

This anti-MBNL1 antibody is a 兔多克隆 antibody detecting MBNL1 in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

MBNL1 Antibody (C-term) (ABIN1881533 and ABIN2838935) western blot analysis in Jurkat cell line lysates (35 μg/lane). (MBNL1 抗体 (C-Term))

1 image

(5 references)

产品编号 ABIN1881533

发货至: 中国

Quick Overview for MBNL1 抗体 (C-Term) (ABIN1881533)

抗原

See all MBNL1 抗体

MBNL1 (Muscleblind-like Protein 1 (MBNL1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This MBNL1 antibody is un-conjugated

应用范围

Western Blotting (WB)

克隆位点

RB42214

Discover our top product MBNL1 Primary Antibody

抗原表位
8

8

5

1

1

1

1

1

1

1
AA 255-284, C-Term

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1.

亚型

Ig Fraction
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibody
MBNL1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-383) antibody
MBNL1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (Middle Region) antibody
MBNL1 适用: 人, 大鼠, 小鼠, 犬, 马, Pig, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (C-Term) antibody
MBNL1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibody
MBNL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-343) antibody
MBNL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (AA 211-260) antibody
MBNL1 适用: 人, 大鼠, 犬, 马, Pig, 兔, 斑马鱼, 猴, Bat, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibody
MBNL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) antibody
MBNL1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated

anti-Muscleblind-like Protein 1 (MBNL1) antibody
MBNL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Sen, Talukdar, Liu, Tam, Reddy, Webster: "Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25426-37, (2010) (PubMed).

Arambula, Ramisetty, Baranger, Zimmerman: "A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 38, pp. 16068-73, (2009) (PubMed).

Cardani, Baldassa, Botta, Rinaldi, Novelli, Mancinelli, Meola: "Ribonuclear inclusions and MBNL1 nuclear sequestration do not affect myoblast differentiation but alter gene splicing in myotonic dystrophy type 2." in: Neuromuscular disorders : NMD, Vol. 19, Issue 5, pp. 335-43, (2009) (PubMed).

Holt, Jacquemin, Fardaei, Sewry, Butler-Browne, Furling, Brook, Morris: "Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle." in: The American journal of pathology, Vol. 174, Issue 1, pp. 216-27, (2009) (PubMed).

Teplova, Patel: "Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1." in: Nature structural & molecular biology, Vol. 15, Issue 12, pp. 1343-51, (2008) (PubMed).
抗原

MBNL1 (Muscleblind-like Protein 1 (MBNL1))

别名

MBNL1

背景

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.

分子量

41817

NCBI登录号

NP_066368, NP_997175, NP_997176, NP_997177, NP_997178, NP_997179, NP_997180

UniProt

Q9NR56

途径

Ribonucleoprotein Complex Subunit Organization