MBNL1 抗体 (C-Term)
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北京 101111
Quick Overview for MBNL1 抗体 (C-Term) (ABIN1881533)
抗原
See all MBNL1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 255-284, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MBNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human MBNL1.
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亚型
- Ig Fraction
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anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibody
MBNL1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) antibodyMBNL1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 24GB610 unconjugated Recombinant Antibody
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-383) antibodyMBNL1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (C-Term) antibodyMBNL1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (Middle Region) antibodyMBNL1 适用: 人, 大鼠, 小鼠, 犬, 马, Pig, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibodyMBNL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibodyMBNL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) antibodyMBNL1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-343) antibodyCell Culture Grade MBNL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 211-260) antibodyMBNL1 适用: 人, 大鼠, 犬, 马, Pig, 兔, 斑马鱼, 猴, Bat, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25426-37, (2010) (PubMed).
: "A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 38, pp. 16068-73, (2009) (PubMed).
: "Ribonuclear inclusions and MBNL1 nuclear sequestration do not affect myoblast differentiation but alter gene splicing in myotonic dystrophy type 2." in: Neuromuscular disorders : NMD, Vol. 19, Issue 5, pp. 335-43, (2009) (PubMed).
: "Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle." in: The American journal of pathology, Vol. 174, Issue 1, pp. 216-27, (2009) (PubMed).
: "Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1." in: Nature structural & molecular biology, Vol. 15, Issue 12, pp. 1343-51, (2008) (PubMed).
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: "Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25426-37, (2010) (PubMed).
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- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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别名
- MBNL1
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背景
- Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
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分子量
- 41817
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NCBI登录号
- NP_066368, NP_997175, NP_997176, NP_997177, NP_997178, NP_997179, NP_997180
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UniProt
- Q9NR56
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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