LGMN 抗体 (N-Term)
(3 references)Quick Overview for LGMN 抗体 (N-Term) (ABIN1881495)
抗原
See all LGMN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 83-112, N-Term
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预测反应
- Pr
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This LGMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human LGMN.
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亚型
- Ig Fraction
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anti-Legumain (LGMN) (AA 18-433) antibody
LGMN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 18-435) antibodyLGMN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 201-300) antibodyLGMN 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 18-323) antibodyLGMN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) antibodyLGMN 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 1-433) antibodyLGMN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 1-433) antibodyLGMN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 1-433) antibodyLGMN 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 199-312) antibodyLGMN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Legumain (LGMN) (AA 83-112) antibodyLGMN 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).
: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).
: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, (2005) (PubMed).
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: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." in: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).
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- LGMN (Legumain (LGMN))
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别名
- LGMN
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背景
- This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
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分子量
- 49411
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NCBI登录号
- NP_001008530, NP_005597
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UniProt
- Q99538
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途径
- Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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