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EXOSC2 抗体 (N-Term)

This anti-EXOSC2 antibody is a 兔 多克隆 antibody detecting EXOSC2 in WB. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1881328
发货至: 中国

Quick Overview for EXOSC2 抗体 (N-Term) (ABIN1881328)

抗原

See all EXOSC2 抗体
EXOSC2 (Exosome Component 2 (EXOSC2))

适用

  • 22
  • 7
  • 5
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  • 3
  • 2
  • 1
  • 1
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宿主

  • 15
  • 7

克隆类型

  • 15
  • 7
多克隆

标记

  • 22
This EXOSC2 antibody is un-conjugated

应用范围

  • 19
  • 9
  • 7
  • 6
  • 5
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  • 1
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Western Blotting (WB)
  • 抗原表位

    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This EXOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EXOSC2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

    Mitchell, Petfalski, Shevchenko, Mann, Tollervey: "The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases." in: Cell, Vol. 91, Issue 4, pp. 457-66, (1997) (PubMed).

  • 抗原

    EXOSC2 (Exosome Component 2 (EXOSC2))

    别名

    EXOSC2

    背景

    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

    分子量

    32789

    NCBI登录号

    NP_055100

    UniProt

    Q13868

    途径

    SARS-CoV-2 Protein Interactome
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