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CXCR4 抗体 (N-Term)

CXCR4 适用: 人 WB 宿主: 兔 Polyclonal RB41207 unconjugated
产品编号 ABIN1881244
发货至: 中国
  • 抗原 See all CXCR4 抗体
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    抗原表位
    • 17
    • 15
    • 15
    • 12
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-79, N-Term
    适用
    • 135
    • 83
    • 65
    • 21
    • 10
    • 10
    • 9
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 116
    • 22
    • 10
    • 5
    • 1
    克隆类型
    • 125
    • 29
    多克隆
    标记
    • 93
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CXCR4 antibody is un-conjugated
    应用范围
    • 108
    • 50
    • 46
    • 35
    • 27
    • 26
    • 25
    • 25
    • 18
    • 11
    • 9
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB)
    预测反应
    B, Pr, M, Pig, Rat, Sh
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This CXCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CXCR4.
    克隆位点
    RB41207
    亚型
    Ig Fraction
    Top Product
    Discover our top product CXCR4 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Zhou, Liu, Li, Zhang, Wang, Lan, Shi, Li, Ju: "Migration ability and Toll-like receptor expression of human mesenchymal stem cells improves significantly after three-dimensional culture." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 323-328, (2017) (PubMed).

    Zhu, Hong, Tripathi, Sehdev, Belkhiri, El-Rifai: "Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells." in: Molecular cancer research : MCR, Vol. 11, Issue 1, pp. 86-94, (2013) (PubMed).

    Hammad, Kuang, Yan, Allen, Dupré: "Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34653-64, (2010) (PubMed).

    Wang, Guilpain, Chong, Chouzenoux, Guillevin, Du, Zhou, Lin, Fairhurst, Boudreaux, Roux, Wakeland, Davis, Batteux, Mohan: "Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus." in: Arthritis and rheumatism, Vol. 62, Issue 11, pp. 3436-46, (2010) (PubMed).

    Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." in: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

    Sanematsu, Hirashima, Laurin, Takii, Nishikimi, Kitajima, Ding, Noda, Murata, Tanaka, Masuko, Suda, Meno, C��té, Nagasawa, Fukui: "DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4." in: Circulation research, Vol. 107, Issue 9, pp. 1102-5, (2010) (PubMed).

  • 抗原
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    别名
    CXCR4 (CXCR4 产品)
    背景
    This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
    分子量
    39746
    NCBI登录号
    NP_001008540, NP_003458
    UniProt
    P61073
    途径
    Regulation of Cell Size, CXCR4-mediated Signaling Events
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