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LPAR1 抗体 (C-Term)

The 兔 多克隆 anti-LPAR1 antibody is suitable to detect LPAR1 in samples from 人 和 大鼠. It has been validated for WB.
产品编号 ABIN187787
发货至: 中国
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北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for LPAR1 抗体 (C-Term) (ABIN187787)

抗原

See all LPAR1 抗体
LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

适用

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人, 大鼠

宿主

  • 51
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克隆类型

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多克隆

标记

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This LPAR1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    C-Term

    特异性

    Reacts with EDG-2. Species Reactivity: Human and Rat. Other species not tested.

    过滤

    0.2 μm filtered

    免疫原

    KLH conjugated synthetic peptide corresponding to the AA 328-344 of human EDG-2.
  • 限制

    仅限研究用
  • 缓冲液

    Rabbit polyclonal antibody against human endothelial cell differentiation gene 2 (CT). This antibody is provided as a 0.2 µm sterile-filtered solution in PBS with 0.08% sodium azide at a concentration of 1 mg/mL. Assayed to be >95% purity by SDS PAGE.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

    别名

    EDG-2 / LPAR1

    背景

    Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduction decreases in c[AMP]i through Gi and increases in [Ca+2]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

    途径

    Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
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