LPAR1 抗体 (C-Term)
Quick Overview for LPAR1 抗体 (C-Term) (ABIN187787)
抗原
See all LPAR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Reacts with EDG-2. Species Reactivity: Human and Rat. Other species not tested.
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过滤
- 0.2 μm filtered
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免疫原
- KLH conjugated synthetic peptide corresponding to the AA 328-344 of human EDG-2.
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限制
- 仅限研究用
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缓冲液
- Rabbit polyclonal antibody against human endothelial cell differentiation gene 2 (CT). This antibody is provided as a 0.2 µm sterile-filtered solution in PBS with 0.08% sodium azide at a concentration of 1 mg/mL. Assayed to be >95% purity by SDS PAGE.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
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别名
- EDG-2 / LPAR1
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背景
- Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduction decreases in c[AMP]i through Gi and increases in [Ca+2]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.
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途径
- Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
抗原
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