Reacts with the 140 kDa desmoglein 3 protein. Does not cross-react with desmoglein 1 or desmoglein 2. The antibody does not inhibit biological activity of desmoglein 3. Species Reactivity: Human. Others not tested.
Immunofluorescence: Use at a 1:10 dilution Immunohistochemistry (paraffin embedded sections) Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.
限制
仅限研究用
状态
Liquid
缓冲液
1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer and 0.02% sodium azide.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments.