F11R 抗体
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- 抗原 See all F11R 抗体
- F11R (F11 Receptor (F11R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This F11R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
- 特异性
- Recognizes human JAM-1. Species Reactivity: Human. Others not tested.
- 过滤
- 0.2 μm filtered
- 克隆位点
- M-Ab-F11
- 亚型
- IgG1
- Top Product
- Discover our top product F11R Primary Antibody
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anti-F11 Receptor (F11R) (AA 1-299) antibody
F11R 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2E3-1C8 unconjugated
anti-F11 Receptor (F11R) (AA 30-238) antibodyF11R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (Internal Region) antibodyF11R 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 64-249) antibodyF11R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (pTyr280) antibodyF11R 适用: 人 WB, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 31-224) antibodyF11R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 小鼠 FACS, IP, IHC (fro) 宿主: 大鼠 Monoclonal H202-106 unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Flow cytometry: Use at a 1:10 dilution. Immunoprecipitation Functional application: Antibody directly stimulates the aggregation and granule secretion of human platelets. Western blotting: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 1 mL of 100 µg/mL 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer.
- 储存条件
- 4 °C
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- 抗原
- F11R (F11 Receptor (F11R))
- 别名
- CD321 / JAM1 (F11R 产品)
- 背景
- Junctional adhesion molecule-1 (JAM-1) is a cell adhesion molecule (CAM). JAM-1 is a member of the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-1 belongs together with JAM-2 and JAM-3 to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. In humans JAM-1 plays a role in platelet aggregation, secretion, adhesion and spreading. JAM-1 is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Antibody-induced platelet aggregation and secretion both depend on FcgammaRII and GPIIb/IIIa intergrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias. Antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor and that appears to place a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the JAM-1 protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the JAM-1 antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). Recent data suggests a role for JAM-1 in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induces in non-denuded blood vessels by inflammatory processes.
- 途径
- Cell-Cell Junction Organization
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