HAVCR1 抗体
Quick Overview for HAVCR1 抗体 (ABIN1819178)
抗原
See all HAVCR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Clone RMT1-10 specifically recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Clone RMT1-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies see for details. Clone RMT1-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies see for details.
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纯化方法
- Protein G purified
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免疫原
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Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Type of Immunogen: Recombinant protein -
亚型
- IgG2a
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anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 332-348), (C-Term) antibody
HAVCR1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-240) antibodyHAVCR1 适用: 人 WB 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 22-235) antibodyHAVCR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 1-364) antibodyHAVCR1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 70-290) antibodyHAVCR1 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 3D9F5 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 70-290) antibodyHAVCR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3A12E10 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-240) antibodyHAVCR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-293) antibodyHAVCR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 22-235) antibodyHAVCR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C8 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-290) antibodyHAVCR1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Target Species of Antibody: Mouse
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
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别名
- HAVCR1 / KIM-1
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物质类
- Virus
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背景
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Name/Gene ID: HAVCR1
Synonyms: HAVCR1, HAVCR-1, KIM-1, Kidney injury molecule 1, KIM1, T-cell membrane protein 1, TIM1, TIMD1, TIM-1, HAVCR, TIMD-1 -
基因ID
- 26762
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UniProt
- Q96D42
抗原
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