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CD68 抗体 (Biotin)

CD68 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal FA-11 Biotin
产品编号 ABIN181833
发货至: 中国
  • 抗原 See all CD68 抗体
    CD68 (CD68 Molecule (CD68))
    适用
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    小鼠
    宿主
    • 89
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    大鼠
    克隆类型
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    单克隆
    标记
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    This CD68 antibody is conjugated to Biotin
    应用范围
    • 76
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    Flow Cytometry (FACS)
    特异性
    This antibody does detect surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.
    纯化方法
    Affinity chromatography on Protein G
    克隆位点
    FA-11
    亚型
    IgG2a
    Top Product
    Discover our top product CD68 Primary Antibody
  • 应用备注
    Flow Cytometry: Neat - 1/10, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL,Membrane permeabilisation is required for this application, The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Kirby, Beattie, Maroof, van Rooijen, Kaye: "SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages." in: The American journal of pathology, Vol. 175, Issue 3, pp. 1107-15, (2009) (PubMed).

  • 抗原
    CD68 (CD68 Molecule (CD68))
    别名
    CD68 (CD68 产品)
    别名
    Lamp4 antibody, Scard1 antibody, gp110 antibody, GP110 antibody, LAMP4 antibody, SCARD1 antibody, CD68 molecule antibody, CD68 antigen antibody, Cd68 molecule antibody, CD68 antibody, Cd68 antibody
    背景
    The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. Macrosialin is the murine homologue of the human macrophage glycoprotein CD68, both are members of the lysosomal-associated membrane protein (lamp) family which are located predominantly within the cells and can be detected by flow cytometry using cell permeablisation.Synonyms: Gp110, Macrophage marker, Macrosialin
    基因ID
    12514
    NCBI登录号
    NP_033983
    UniProt
    P31996
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