Soluble Terminal Complement Complex (sC5b-9) 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in FACS, IHC (fro), WB 和 EIA. Suitable for 人.
Quick Overview for Soluble Terminal Complement Complex (sC5b-9) 抗体 (ABIN181111)
抗原
Soluble Terminal Complement Complex (sC5b-9)
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Enzyme Immunoassay (EIA)
克隆位点
3R2-0
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产品特性
- Synonyms: Terminal complement complex, Membrane attack complex
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纯化方法
- Affinity Chromatography on Protein A
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亚型
- IgG2b
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应用备注
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ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Borate buffered saline, pH 8.4 containing 0.09 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- Soluble Terminal Complement Complex (sC5b-9)
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别名
- Complement SC5b-9 (TCC / MAC)
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背景
- Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Synonyms: Membrane attack complex, Terminal complement complex
抗原
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