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Abeta 38/40/42 (AA 1-16) 抗体

Cited in 4+ publications. The 小鼠 单克隆 anti-Abeta 38/40/42 antibody (Clone NT244) (ABIN1742439) specifically detects Abeta 38/40/42 in IHC, IHC (p), ELISA, WB 和 ICC. The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN1742439
发货至: 中国
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Quick Overview for Abeta 38/40/42 (AA 1-16) 抗体 (ABIN1742439)

抗原

Abeta 38/40/42

适用

人, 小鼠

宿主

  • 2
小鼠

克隆类型

  • 2
单克隆

标记

  • 1
  • 1
非结合性

应用范围

Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB), Immunocytochemistry (ICC)

克隆位点

NT244
  • 抗原表位

    AA 1-16

    原理

    Mouse anti-Abeta38/40/42/43 IgG

    特异性

    Specific for Abeta 38, 40, 42.

    交叉反应 (详细)

    Reacts with: human (P05067), mouse (P12023). Other species not tested yet.

    纯化方法

    purified IgG

    免疫原

    Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067) Epitop AA 4 to 8 from human Abeta (UniProt Id: P05067)

    亚型

    IgG2b
  • 应用备注

    WB:1 : 500 up to 1 : 1000

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

    缓冲液

    PBS. Azide was added before lyophilization.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

    储存条件

    -20 °C,-80 °C,4 °C

    储存方法

    Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Do not freeze!
  • Porcellotti, Fanelli, Fracassi, Sepe, Cecconi, Bernardi, Cimini, Cerù, Moreno: "Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease." in: Oxidative medicine and cellular longevity, Vol. 2015, pp. 967203, (2015) (PubMed).

    Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, (2014) (PubMed).

    Wirths, Hillmann, Pradier, Härtig, Bayer: "Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy." in: Journal of Alzheimer's disease : JAD, Vol. 35, Issue 4, pp. 741-9, (2013) (PubMed).

    Venkataramani, Wirths, Budka, Härtig, Kovacs, Bayer: "Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates." in: Journal of Alzheimer's disease : JAD, Vol. 29, Issue 2, pp. 361-71, (2012) (PubMed).

  • 抗原

    Abeta 38/40/42

    背景

    Synonyms: Beta-APP, ABPP, Abeta, Abeta 38, Abeta 40, Abeta 42, Abeta 43

    Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

    UniProt

    P05067
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