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Abeta 38/40/42 (AA 1-16) 抗体

This 小鼠 单克隆 antibody specifically detects Abeta 38/40/42 in IHC, IHC (p), ELISA 和 WB. It exhibits reactivity toward 人 和 小鼠. It has been mentioned in 2+ publications
产品编号 ABIN1742437
发货至: 中国
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Quick Overview for Abeta 38/40/42 (AA 1-16) 抗体 (ABIN1742437)

抗原

Abeta 38/40/42

适用

人, 小鼠

宿主

  • 2
小鼠

克隆类型

  • 2
单克隆

标记

  • 1
  • 1
非结合性

应用范围

  • 2
  • 2
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)

克隆位点

NT78
  • 抗原表位

    AA 1-16

    原理

    Mouse anti-Abeta38/40/42/43 IgG

    特异性

    Specific for Abeta 38, 40, 42.

    交叉反应 (详细)

    Reacts with: human (P05067), mouse (P12023). Other species not tested yet.

    纯化方法

    purified IgG

    免疫原

    Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067) Epitop AA 4 to 16 from human Abeta (UniProt Id: P05067)

    亚型

    IgG2b
  • 应用备注

    WB:1 : 500 up to 1 : 1000 ,

    说明

    ELISA: Suitable as capture antibody for sandwich-ELISA as detector antibody (protocol for sandwich-ELISA).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

    缓冲液

    PBS. Azide was added before lyophilization.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

    储存条件

    -20 °C,-80 °C,4 °C

    储存方法

    Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Do not freeze!
  • Jawhar, Wirths, Schilling, Graubner, Demuth, Bayer et al.: "Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in ..." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4454-60, (2011) (PubMed).

    Wirths, Erck, Martens, Harmeier, Geumann, Jawhar, Kumar, Multhaup, Walter, Ingelsson, Degerman-Gunnarsson, Kalimo, Huitinga, Lannfelt, Bayer: "Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis." in: The Journal of biological chemistry, Vol. 285, Issue 53, pp. 41517-24, (2010) (PubMed).

  • 抗原

    Abeta 38/40/42

    背景

    Synonyms: Beta-APP, ABPP, Abeta, Abeta 38, Abeta 40, Abeta 42, Abeta 43

    Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

    UniProt

    P05067
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