SHANK3 抗体 (AA 1055-1616)
Quick Overview for SHANK3 抗体 (AA 1055-1616) (ABIN1742347)
抗原
See all SHANK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1055-1616
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特异性
- Specific for shank 3.
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纯化方法
- antiserum
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免疫原
- Recombinant protein (aa 1055-1616 of rat shank 3).
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应用备注
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WB: 1 : 1000 (AP staining)
IP: not tested yet
ICC: 1 : 500
IHC: 1 : 500 -
说明
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IHC: For best results the antibody requires a mild fixation protocol (2 % PFA in sodium acetate buffer, pH 6).
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS
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注意事项
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Crude antisera are more robust than monoclonals. With anti-microbials added, they may be stored at 4 °C.
Serum does not contain active proteases, in fact, serum itself contains a powerful cocktail of protease inhibitors. Frozen storage (-20 °C),however, is preferable. -
储存条件
- 4 °C/-20 °C
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储存方法
- Unlabeled antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4 °C for several years.
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: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." in: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, (2016) (PubMed).
: "Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder." in: Neurochemical research, Vol. 41, Issue 11, pp. 3129-3137, (2016) (PubMed).
: "Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism." in: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 1918-25, (2016) (PubMed).
: "Effects of trace metal profiles characteristic for autism on synapses in cultured neurons." in: Neural plasticity, Vol. 2015, pp. 985083, (2015) (PubMed).
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: "Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses." in: PLoS ONE, Vol. 11, Issue 5, pp. e0153979, (2016) (PubMed).
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- SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
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别名
- Shank 3
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背景
- Synonyms: ProSAP2, SPANK2
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途径
- Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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