Protocadherin gamma 抗体 (AA 808-931) (APC)
Quick Overview for Protocadherin gamma 抗体 (AA 808-931) (APC) (ABIN1741189)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 808-931
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特异性
- Detects ~100 kDa. Cross-reacts with all Gamma-protocadherin-A, -B and -C proteins.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein G Purified
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免疫原
- Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941). 99% identity with human (123/124 amino acids).
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亚型
- IgG1
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anti-Protocadherin gamma (AA 808-931) antibody
适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 unconjugated
anti-Protocadherin gamma (AA 808-931) antibody (HRP)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 HRP
anti-Protocadherin gamma (AA 808-931) antibody (FITC)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 FITC
anti-Protocadherin gamma (AA 808-931) antibody (Biotin)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 Biotin
anti-Protocadherin gamma (AA 808-931) antibody (PE)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 PE
anti-Protocadherin gamma (AA 808-931) antibody (PerCP)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 PerCP
anti-Protocadherin gamma (AA 808-931) antibody (Atto 488)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 Atto 488
anti-Protocadherin gamma (AA 808-931) antibody (Atto 594)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 Atto 594
anti-Protocadherin gamma (AA 808-931) antibody (Atto 390)适用: 小鼠 IHC, WB, ICC, IF 宿主: 小鼠 Monoclonal S159-5 Atto 390
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应用备注
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
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说明
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1 μg/ml of ABIN1741189 was sufficient for detection of Protocadherin gamma (pan) in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Conjugated antibodies should be stored at 4°C
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- Protocadherin gamma
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背景
- The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
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基因ID
- 93709
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NCBI登录号
- NP_291062
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UniProt
- Q91XZ0
抗原
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