Metabotropic Glutamate Receptor 1 抗体 (AA 1159-1171)
Quick Overview for Metabotropic Glutamate Receptor 1 抗体 (AA 1159-1171) (ABIN1736899)
抗原
See all Metabotropic Glutamate Receptor 1 (GRM1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1159-1171
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特异性
- Reacts with GluR1 protein form human, mouse and rat
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纯化方法
- Antigen affinity purified
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免疫原
- Synthetic peptide comprising residues 1159-1171 [SSVPSSPVSESVL] of the human GluR1 protein.
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亚型
- IgG
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应用备注
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- IHC : 1/100 to 1/500 - WB : 1/500 to 1/1000 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, Sodium azide 0.02 %
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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有效期
- 6 months
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- Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
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别名
- Metabotropic Glutamate Receptor 1a (mGluR1)
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背景
- The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors.Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C.Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined.Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.mGluR1 has been reported in various regions of the brain and spinal cord.ESTs have been isolated from brain and eye libraries.Caution:GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).
抗原
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