KLF1 抗体 (AA 208-362)
Quick Overview for KLF1 抗体 (AA 208-362) (ABIN1724828)
抗原
See all KLF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 208-362
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原理
- KLF1 Antibody
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纯化方法
- Purified antibody
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免疫原
- Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. Coli.
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24819-27, (2011) (PubMed).
: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, (2010) (PubMed).
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: "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding." in: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24819-27, (2011) (PubMed).
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- KLF1 (Kruppel-Like Factor 1 (erythroid) (KLF1))
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别名
- KLF1
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背景
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This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
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分子量
- 38.2 kDa
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UniProt
- Q13351
抗原
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