GAB3 抗体 (AA 31-130)
Quick Overview for GAB3 抗体 (AA 31-130) (ABIN1714787)
抗原
See all GAB3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-130
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GAB3
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亚型
- IgG
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anti-GRB2-Associated Binding Protein 3 (GAB3) (AA 142-375) antibody
GAB3 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-GRB2-Associated Binding Protein 3 (GAB3) (AA 332-583) antibodyGAB3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GAB3 (GRB2-Associated Binding Protein 3 (GAB3))
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别名
- GAB3
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背景
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Synonyms: Gab3, GAB3_HUMAN, GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3.
Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (13). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (13). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).
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基因ID
- 139716
抗原
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