AIRE 抗体 (AA 51-150)
-
- 抗原 See all AIRE 抗体
- AIRE (Autoimmune Regulator (AIRE))
-
抗原表位
- AA 51-150
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This AIRE antibody is un-conjugated
-
应用范围
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human AIRE
- 亚型
- IgG
- Top Product
- Discover our top product AIRE Primary Antibody
-
anti-Autoimmune Regulator (AIRE) (C-Term) antibody
Verified AIRE 适用: 人 WB, ELISA, IF, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 30-130) antibodyAIRE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (N-Term) antibodyAIRE 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (Internal Region) antibodyAIRE 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (Internal Region) antibodyVerified AIRE 适用: 人, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 39-108) antibodyAIRE 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (pSer156) antibodyAIRE 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 467-516) antibodyAIRE 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) (AA 218-267) antibodyAIRE 适用: 人, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Autoimmune Regulator (AIRE) antibodyAIRE 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
-
- 抗原
- AIRE (Autoimmune Regulator (AIRE))
- 别名
- AIRE (AIRE 产品)
- 别名
- AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
- 背景
-
Synonyms: AIRE-1, AIRE, AIRE_HUMAN, AIRE1, APECED, APECED protein, APS1, APSI, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator, Autoimmune regulator protein, PGA1.
Background: The autoimmune regulator gene, which is defective in the hereditary auto-immune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, with lower expression in the spleen, fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, where it is modulated by thymocytes undergoing negative selection. At the cellular level, AIRE is located in microtubular structures of the cyto-skeleton and in discrete nuclear dots resembling ND10 nuclear bodies. AIRE is induced by developing early thymocytes and is associated with the correct establishment of a regular thymic environment. AIRE regulates thymic architecture via transcriptional control of downstream target genes. AIRE mutations in APECED patients may affect thymic T cell selection and the formation of self-tolerance.
- 基因ID
- 326
- 途径
- Chromatin Binding
-
