HDAC7 抗体 (pSer486)
Quick Overview for HDAC7 抗体 (pSer486) (ABIN1714079)
抗原
See all HDAC7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer486
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预测反应
- Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser632
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- HDAC7 (Histone Deacetylase 7 (HDAC7))
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别名
- HDAC7
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背景
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Synonyms: HDAC7 phospho S486, HDAC7 phospho Ser486, p-HDAC7 Ser486, HD 7a, HD7a, HDAC 7, HDAC 7A, HDAC7, HDAC7A, Histone deacetylase 7, Histone deacetylase 7A, DKFZP586J0917, OTTHUMP00000202813, OTTHUMP00000202814, FLJ99588, HDAC7_HUMAN.
Background: HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.
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基因ID
- 51564
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途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development
抗原
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