DMAP1 抗体 (AA 31-130)
Quick Overview for DMAP1 抗体 (AA 31-130) (ABIN1714047)
抗原
See all DMAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-130
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交叉反应
- 非洲爪蟾
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DMAP1
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亚型
- IgG
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))
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别名
- DMAP1
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背景
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Synonyms: DKFZp686L09142, DMAP 1, DNA methyltransferase 1-associated protein 1, DNMAP 1, DNMAP1, DNMT1-associated protein 1, DNMT1-associated protein 1, DNMTAP 1, DNMTAP1, EAF 2, EAF2, FLJ11543, KIAA1425, MAT 1-mediated transcriptional repressor, MGC55593, SWC 4, SWC4, zgc:55593.
Background: Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo.
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基因ID
- 55929
抗原
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