GRB7 抗体 (AA 231-330)
Quick Overview for GRB7 抗体 (AA 231-330) (ABIN1713833)
抗原
See all GRB7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 231-330
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GRB7
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 298-489) antibody
GRB7 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 66-327) antibodyGRB7 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 37-136) antibodyGRB7 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 233-532) antibodyGRB7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) antibodyGRB7 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 124-141), (Middle Region) antibodyGRB7 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (N-Term) antibodyGRB7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (N-Term) antibodyVerified GRB7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
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别名
- GRB7
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背景
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Synonyms: B47, Epidermal growth factor receptor GRB 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7, GRB7_HUMAN, Growth factor receptor bound protein 7, Growth factor receptor-bound protein 7, OTTHUMP00000164349, OTTHUMP00000164350, OTTHUMP00000164351, OTTHUMP00000164352.
Background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6).
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途径
- EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
抗原
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