IFI30 抗体 (AA 181-250) (HRP)
Quick Overview for IFI30 抗体 (AA 181-250) (HRP) (ABIN1711361)
抗原
See all IFI30 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 181-250
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human IFI30
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亚型
- IgG
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anti-Interferon, gamma-Inducible Protein 30 (IFI30) (AA 1-250) antibody
IFI30 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 30 (IFI30) (AA 1-250) antibodyIFI30 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 30 (IFI30) (AA 1-250) antibodyIFI30 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 30 (IFI30) (Center) antibodyIFI30 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon, gamma-Inducible Protein 30 (IFI30) (AA 1-250) antibodyIFI30 适用: 人 FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- IFI30 (Interferon, gamma-Inducible Protein 30 (IFI30))
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别名
- I30
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背景
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Synonyms: Gamma interferon inducible lysosomal thiol reductase, Gamma interferon inducible protein IP 30, GILT, I 30, interferon gamma inducible protein 30, Interferon gamma inducible protein 30 preproprotein, IP30, Lysosomal thiol reductase, Lysosomal thiol reductase, gamma-interferon-inducible.
Background: Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin. In the endocytic pathway, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes. This process is catalyzed by a gamma-interferon-inducible thiol reductase (GILT). GILT is synthesized as a precursor, and following delivery to MHC class II-containing compartments (MIICs), is processed to the mature form via cleavage of amino- and carboxy-terminal propeptides. A lysosomal thiol reductase, GILT, is optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. GILT is expressed constitutively in antigen-presenting cells and is induced by g-interferon in other cell types, suggesting a potentially important role in antigen processing. Additionally, T cell recognition of select exogenous and endogenous epitopes is dependent on tumor cell expression of GILT. The absence of GILT in melanomas alters antigen processing and the hierarchy of immunodominant epitope presentation.
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基因ID
- 10437
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UniProt
- P13284
抗原
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