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IKAP/p150 抗体 (AA 1151-1250) (FITC)

This anti-IKAP/p150 antibody is a 兔 多克隆 antibody detecting IKAP/p150 in WB, IF (cc) 和 IF (p). Suitable for 小鼠 和 大鼠.
产品编号 ABIN1709549
发货至: 中国

Quick Overview for IKAP/p150 抗体 (AA 1151-1250) (FITC) (ABIN1709549)

抗原

See all IKAP/p150 (ELP1) 抗体
IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

适用

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  • 24
  • 18
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
小鼠, 大鼠

宿主

  • 42
  • 3
  • 3

克隆类型

  • 45
  • 3
多克隆

标记

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  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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This IKAP/p150 antibody is conjugated to FITC

应用范围

  • 37
  • 19
  • 12
  • 12
  • 10
  • 6
  • 5
  • 5
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 14
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1151-1250

    交叉反应

    小鼠, 大鼠

    预测反应

    Human,Rabbit

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human IKAP

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))

    别名

    IKAP

    背景

    Synonyms: DKFZp781H1425, DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, Elongator complex protein 1, ELP 1, ELP1, ELP1_HUMAN, FD, FLJ12497, IKAP, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, ikbkap, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, p150, TOT 1, TOT1

    Background: The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)

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