Hephaestin 抗体 (AA 21-120) (Cy7)
Quick Overview for Hephaestin 抗体 (AA 21-120) (Cy7) (ABIN1708977)
抗原
See all Hephaestin (HEPH) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-120
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交叉反应
- 人, 小鼠
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预测反应
- Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Hephaestin
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亚型
- IgG
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anti-Hephaestin (HEPH) (AA 315-424) antibody
HEPH 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D3 unconjugated
anti-Hephaestin (HEPH) (AA 21-120) antibodyHEPH 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hephaestin (HEPH) (AA 300-580) antibodyHEPH 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hephaestin (HEPH) (AA 24-366) antibodyHEPH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hephaestin (HEPH) (AA 315-424) antibodyHEPH 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Hephaestin (HEPH)
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别名
- Hephaestin
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背景
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Synonyms: CPL, HEPH, HEPH_HUMAN, Hephaestin.
Background: Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.
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基因ID
- 9843
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途径
- Transition Metal Ion Homeostasis
抗原
-
