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SUMO2 抗体 (Cy7)

This anti-SUMO2 antibody is a 兔 多克隆 antibody detecting SUMO2 in IF (p). Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN1708943
发货至: 中国

Quick Overview for SUMO2 抗体 (Cy7) (ABIN1708943)

抗原

See all SUMO2 抗体
SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

  • 80
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多克隆

标记

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This SUMO2 antibody is conjugated to Cy7

应用范围

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Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Sumo 2

    亚型

    IgG
  • 应用备注

    IF(IHC-P): 1:50-200
    Optimal working dilution should be determined by the investigator.

    说明

    Exitation/Emission: 743nm/767nm

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at 4 °C

    有效期

    12 months
  • 抗原

    SUMO2 (Small Ubiquitin Related Modifier 2 (SUMO2))

    别名

    Sumo 2

    背景

    The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease


    Synonyms: Small ubiquitin-related modier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3A, Smt3A, SUMO2_HUMAN.

    基因ID

    6613

    途径

    Methionine Biosynthetic Process
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