NLE1 抗体 (AA 351-450) (Cy7)
Quick Overview for NLE1 抗体 (AA 351-450) (Cy7) (ABIN1708936)
抗原
See all NLE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 351-450
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human NLE1
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亚型
- IgG
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anti-Notchless Homolog 1 (NLE1) (AA 206-485) antibody
NLE1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notchless Homolog 1 (NLE1) (AA 206-485) antibodyNLE1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Notchless Homolog 1 (NLE1) (Internal Region) antibodyNLE1 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Notchless Homolog 1 (NLE1) (AA 351-400) antibodyNLE1 适用: 人, 小鼠, 大鼠, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Notchless Homolog 1 (NLE1) (C-Term) antibodyNLE1 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 猴, Cow, 犬, 兔, 斑马鱼, Bat, 小鸡, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- NLE1 (Notchless Homolog 1 (NLE1))
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别名
- NLE1
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背景
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Synonyms: FLJ10458, NLE 1, Nle, Notchless gene homolog, Notchless homolog 1 Drosophila, Notchless homolog 1, Notchless protein homolog 1, NLE1_HUMAN.
Background: The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing.
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基因ID
- 54475
抗原
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