ANAPC10 抗体 (AA 31-130) (Cy7)
Quick Overview for ANAPC10 抗体 (AA 31-130) (Cy7) (ABIN1708179)
抗原
See all ANAPC10 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 31-130
-
交叉反应
- 大鼠
-
预测反应
- Human,Mouse,Cow,Sheep,Pig,Chicken,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human APC10
-
亚型
- IgG
-
-
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (AA 1-185) antibody
ANAPC10 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 8F1D10 unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (AA 1-185) antibodyANAPC10 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (AA 1-185) antibodyANAPC10 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (AA 1-185) antibodyANAPC10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (N-Term) antibodyANAPC10 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 小鸡, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (N-Term) antibodyANAPC10 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Anaphase Promoting Complex Subunit 10 (ANAPC10) (N-Term) antibodyANAPC10 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- ANAPC10 (Anaphase Promoting Complex Subunit 10 (ANAPC10))
-
别名
- APC10
-
背景
-
Synonyms: ANAPC 10, anapc10, Anaphase promoting complex 10, Anaphase promoting complex subunit 10, Anaphase-promoting complex subunit 10, Apc 10, APC10, APC10_HUMAN, Cyclosome subunit 10, DKFZP564L0562, Doc 1, Doc1, OTTHUMP00000220297, OTTHUMP00000220298, OTTHUMP00000220299, OTTHUMP00000220300, OTTHUMP00000220303.
Background: Composed of more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC10 contains a Doc1 homology domain, which is a beta-sandwich structure common to many other putative E3 ubiquitin ligases. APC10 binds to core APC subunits throughout the cell cycle. Specifically, APC10 binds to the C-terminus of CDC27/APC3. During mitosis, APC10 is localized in centrosomes and mitotic spindles. APC10 also localizes to kinetochores from prophase to anaphase, and to the midbody in telophase and cytokinesis.
-
基因ID
- 10393
-
途径
- M Phase
抗原
-
