HIC2 抗体 (AA 501-600) (Cy7)
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北京 101111
Quick Overview for HIC2 抗体 (AA 501-600) (Cy7) (ABIN1708087)
抗原
See all HIC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-600
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预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human HIC2
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亚型
- IgG
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anti-Hypermethylated in Cancer 2 (HIC2) (Middle Region) antibody
HIC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (AA 1-615) antibodyHIC2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) antibodyHIC2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (AA 188-200) antibodyVerified HIC2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (AA 1-100) antibodyHIC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (Internal Region) antibodyHIC2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (AA 252-301) antibodyHIC2 适用: 人, 小鼠, 大鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (C-Term) antibodyHIC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, Pig, 斑马鱼, Bat, 非洲爪蟾, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (AA 395-444) antibodyHIC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Hypermethylated in Cancer 2 (HIC2) (N-Term) antibodyHIC2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- HIC2 (Hypermethylated in Cancer 2 (HIC2))
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别名
- Hic2
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背景
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Synonyms: HIC1 related gene on chromosome 22, HIC2, Hic3, HRG22, Hypermethylated in cancer 2 protein, KIAA1020, ZBTB30, Zinc finger and BTB domain-containing protein 30, ZNF907, HIC2_HUMAN.
Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
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基因ID
- 23119
抗原
-
