GAB4 抗体 (AA 101-200) (Cy5)
Quick Overview for GAB4 抗体 (AA 101-200) (Cy5) (ABIN1704909)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 101-200
-
预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human GAB4
-
亚型
- IgG
-
-
anti-GRB2-Associated Binding Protein Family, Member 4 (GAB4) (AA 64-92), (N-Term) antibody
GAB4 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB29443 unconjugated
anti-GRB2-Associated Binding Protein Family, Member 4 (GAB4) (AA 71-100), (N-Term) antibodyGAB4 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- GAB4 (GRB2-Associated Binding Protein Family, Member 4 (GAB4))
-
别名
- GAB4
-
背景
-
Synonyms: GAB2-like, GAB4, GAB4_HUMAN, GRB2 associated binder 2 like protein, GRB2 associated binding protein family member 4, GRB2-associated binder 2-like, GRB2-associated binder 4, GRB2-associated-binding protein 2-like, GRB2-associated-binding protein 4, Growth factor receptor bound protein 2-associated protein 4.
Background: The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recruit-ment to RTKs. Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur. This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab 1-4 contain Pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins. The recruitment of signaling partners to Gab family members is phosphorylation-dependent. Insulin receptor and EGF receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus. Gab 4 (GRB2-associated-binding protein 4), also designated GRB2-associated-binding protein 2-like (Gab 2-like), is a 574 amino acid protein that shares 62 % sequence similarity with Gab 2 and contains one Pleckstrin homology domain.
-
基因ID
- 128954
抗原
-
