Aconitase 1 抗体 (pSer711) (Cy5)
Quick Overview for Aconitase 1 抗体 (pSer711) (Cy5) (ABIN1704135)
抗原
See all Aconitase 1 (ACO1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer711
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human Aconitase 1 around the phosphorylation site of Ser711 [YG(p-S)RR]
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Aconitase 1 (ACO1)
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别名
- Aconitase 1
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背景
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Synonyms: Aconitase 1 phospho S711, p-Aconitase 1 phospho S711, ACO 1, ACO1, ACOC_HUMAN, Aconitase 1 soluble, Aconitase, Aconitase1, Aconitate hydratase, ACONS, Citrate hydro lyase, Citrate hydro-lyase, Cytoplasmic aconitate hydratase, Ferritin repressor protein, IRE BP 1, IRE-BP 1, IREB 1, IREB1, IREBP, IREBP1, Iron regulatory protein 1, Iron responsive element binding protein 1, Iron-responsive element-binding protein 1, IRP 1, IRP1, OTTHUMP00000045233.
Background: Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins, iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IREBP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
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基因ID
- 48
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途径
- Transition Metal Ion Homeostasis
抗原
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