IKAP/p150 抗体 (AA 1151-1250) (Cy5)
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北京 101111
Quick Overview for IKAP/p150 抗体 (AA 1151-1250) (Cy5) (ABIN1703969)
抗原
See all IKAP/p150 (ELP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1151-1250
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human IKAP
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亚型
- IgG
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anti-Elongator Complex Protein 1 (ELP1) (AA 1107-1258) antibody
ELP1 适用: 人 WB, ELISA, IP, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1242-1331) antibodyELP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6G9 unconjugated
anti-Elongator Complex Protein 1 (ELP1) (AA 1093-1332) antibodyELP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (C-Term) antibodyELP1 适用: 人, 小鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Elongator Complex Protein 1 (ELP1) (C-Term) antibodyELP1 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
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别名
- IKAP
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背景
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Synonyms: DKFZp781H1425, DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, Elongator complex protein 1, ELP 1, ELP1, ELP1_HUMAN, FD, FLJ12497, IKAP, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, ikbkap, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, p150, TOT 1, TOT1
Background: The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)
抗原
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