FUBP1, FUBP2 (AA 551-644) 抗体 (Cy3)
Quick Overview for FUBP1, FUBP2 (AA 551-644) 抗体 (Cy3) (ABIN1703061)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 551-644
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特异性
- This antibody detects both FUBP1 and FUBP2 (KHSRP)
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FUBP1
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- FUBP1, FUBP2
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别名
- FUBP1/2
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背景
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Synonyms: Far upstream element-binding protein 1, FUBP1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V, Far upstream element-binding protein 2, KHSRP, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, FBP2, FUBP2
Background: FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
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基因ID
- 8880
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UniProt
- Q96AE4
抗原
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