SKAP2 抗体 (AA 1-100) (Cy3)
Quick Overview for SKAP2 抗体 (AA 1-100) (Cy3) (ABIN1702204)
抗原
See all SKAP2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-100
-
预测反应
- Human,Mouse,Rat,Dog,Sheep,Horse,Rabbit
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human SCAP2
-
亚型
- IgG
-
-
-
-
应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
- SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))
-
别名
- Scap2
-
背景
-
Synonyms: Fyn associated phosphoprotein SKAP55 homologue, MGC10411, MGC33, PRAP, Pyk2/RAFTK associated protein, Pyk2/RAFTK-associated protein, RA70, Retinoic acid-induced protein 70, SAPS, SKAP-55HOM, SKAP-HOM, skap2, SKAP2_HUMAN, SKAP55 homolog, SKAP55R, Src associated adaptor protein, Src family associated phosphoprotein 2, Src family-associated phosphoprotein 2, src kinase associated phosphoprotein of 55 related protein, Src kinase-associated phosphoprotein 2, Src kinase-associated phosphoprotein 55-related protein, Src-associated adapter protein with PH and SH3 domains.
Background: Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte antigen receptors leading up to T cell activation. The human SKAP55 gene maps to chromosome 17q21.32 and encodes a 359 amino acid protein.
抗原
-