FRAT2 抗体 (AA 131-230) (Biotin)
Quick Overview for FRAT2 抗体 (AA 131-230) (Biotin) (ABIN1701037)
抗原
See all FRAT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-230
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Sheep
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FRAT2
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亚型
- IgG
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anti-Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2) (AA 203-230), (C-Term) antibody
FRAT2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB31392 unconjugated
anti-Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2) (AA 210-233), (C-Term) antibodyFRAT2 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2) (C-Term) antibodyVerified FRAT2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
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别名
- FRAT2
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背景
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Synonyms: Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2, FRAT2_HUMAN.
Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.
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基因ID
- 23401
抗原
-
