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HIC2 抗体 (AA 501-600) (AbBy Fluor® 555)

This anti-HIC2 antibody (ABIN1697070) is a Rabbit Polyclonal antibody detecting HIC2 in WB, IF (cc), IF (p). Suitable for Human.
产品编号 ABIN1697070
发货至: 中国

Quick Overview for HIC2 抗体 (AA 501-600) (AbBy Fluor® 555) (ABIN1697070)

抗原

See all HIC2 抗体
HIC2 (Hypermethylated in Cancer 2 (HIC2))

适用

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宿主

  • 35
  • 5
  • 1

克隆类型

  • 39
  • 2
多克隆

标记

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  • 1
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This HIC2 antibody is conjugated to AbBy Fluor® 555

应用范围

  • 38
  • 18
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  • 2
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  • 1
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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 14
    • 7
    • 3
    • 2
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    • 1
    • 1
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    • 1
    AA 501-600

    预测反应

    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human HIC2

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    HIC2 (Hypermethylated in Cancer 2 (HIC2))

    别名

    Hic2

    背景

    Synonyms: HIC1 related gene on chromosome 22, HIC2, Hic3, HRG22, Hypermethylated in cancer 2 protein, KIAA1020, ZBTB30, Zinc finger and BTB domain-containing protein 30, ZNF907, HIC2_HUMAN.

    Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells. HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.

    基因ID

    23119
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