SMC5 抗体 (AA 872-1101)
Quick Overview for SMC5 抗体 (AA 872-1101) (ABIN1682829)
抗原
See all SMC5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 872-1101
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序列
- LTEERSRASC FTGLNPTIVQ EYTKREEEIE QLTEELKGKK VELDQYRENI SQVKERWLNP LKELVEKINE KFSNFFSSMQ CAGEVDLHTE NEEDYDKYGI RIRVKFRSST QLHELTPHHQ SGGERSVSTM LYLMALQELN RCPFRVVDEI NQGMDPINER RVFEMVVNTA CKENTSQYFF ITPKLLQNLP YSEKMTVLFV YNGPHMLEPN TWNLKAFQRR RRRITFTQPS
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 872-1101 of human SMC5 (NP_055925.2).
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亚型
- IgG
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anti-Structural Maintenance of Chromosomes 5 (SMC5) (Internal Region) antibody
Verified SMC5 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 296-403) antibodySMC5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Structural Maintenance of Chromosomes 5 (SMC5) (AA 992-1101) antibodySMC5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB,1:1000 - 1:3000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))
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别名
- SMC5
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背景
- Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.,SMC5,SMC5L1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,SMC5
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分子量
- 128 kDa
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基因ID
- 23137
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UniProt
- Q8IY18
抗原
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