IFIT3 抗体 (AA 128-331)
Quick Overview for IFIT3 抗体 (AA 128-331) (ABIN1680389)
抗原
See all IFIT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 128-331
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序列
- ANPYSMECPE LECEEGWTRL KCGRNERAKM CFEKALEEKP KDPECSSGMA IAMFRLEEKP EKQFSVDALK QAMELNPQNQ YLKVLLALKL LRMGEEAEGE RLIKDALGKA PNQTDVLQKA AQFYKKKGNL DRAIELLGKA LRSTVNNSPL YSLVMCRYRE ILEQLQNKGD ADSSERRQRM AELRRLTMEF MQKTLQRRRS PLNS
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1).
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亚型
- IgG
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anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibody
IFIT3 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) antibodyIFIT3 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (N-Term) antibodyIFIT3 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibodyIFIT3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 1-490) antibodyIFIT3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (N-Term) antibodyIFIT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 51-100) antibodyIFIT3 适用: 人, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) antibodyIFIT3 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 1G1 unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (C-Term) antibodyIFIT3 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) (AA 392-490) antibodyIFIT3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated
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应用备注
- WB,1:500 - 1:1000,IHC,1:100 - 1:200
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
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别名
- IFIT3
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背景
- IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.,IFIT3,CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,P60,RIG-G,cig41,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,IFIT3
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分子量
- 47 kDa
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基因ID
- 15959
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UniProt
- O14879
抗原
-
