ESAM 抗体
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北京 101111
Quick Overview for ESAM 抗体 (ABIN1589920)
抗原
See all ESAM 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ESAM antibody
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特异性
- Recombinant human ESAM
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产品特性
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Chromosomal location: 11q24.2
Produced from sera of rabbits immunized with highly pure recombinant human soluble ESAM (Endothelial cell-selective adhesion molecule, Q30-A247, SwissProt: #Q96AP7) as the immunizing antigen. -
纯化方法
- Anti-human ESAM was purified by affinity chromatography with immobilized Protein A.
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免疫原
- Recombinant human ESAM (ABIN1589731)
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亚型
- IgG
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anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 29-248) antibody
ESAM 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 21-120) antibodyESAM 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 30-248) antibodyESAM 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 30-248) antibodyESAM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 30-248) antibodyESAM 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1G8 unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 1-390) antibodyESAM 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Endothelial Cell Adhesion Molecule (ESAM) (AA 31-390) antibodyESAM 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: Use 2-5 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- ESAM (Endothelial Cell Adhesion Molecule (ESAM))
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别名
- ESAM
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背景
- ESAM, W117m,Endothelial cell selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules. Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in hemophilic adhesion. In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI1. The extracellular region of human ESAM shows 90 % , 74 %, 69 % and 67 % aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell to cell junctions. Whether ESAM is restricted to a particular junctional type is not clear. ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF2.
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基因ID
- 90952
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NCBI登录号
- NM_138961, NP_620411
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UniProt
- Q96AP7
抗原
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