CCBE1 抗体 (AA 159-251)
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Quick Overview for CCBE1 抗体 (AA 159-251) (ABIN1589917)
抗原
See all CCBE1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 159-251
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原理
- ccbe1 antibody
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特异性
- Recombinant human ccbe1 (Tyr35-Pro406) derived from Sf9 insect cells
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产品特性
- Chromosomal location: 18q21.32
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纯化方法
- Protein A purified
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免疫原
- Highly pure (>98%) recombinant human ccbe1 (Cys159-Leu251) derived from E. coli.
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亚型
- IgG
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应用备注
- Western Blot: Use 2-5 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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注意事项
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))
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别名
- ccbe1
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背景
- Collagen and calcium binding EGF domains 1, KIAA1983,The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migration routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.
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基因ID
- 147372
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NCBI登录号
- NM_133459, NP_597716
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UniProt
- Q6UXH8
抗原
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