ESM1 抗体
Quick Overview for ESM1 抗体 (ABIN1589852)
抗原
See all ESM1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Endocan/ESM-1 antibody
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特异性
- Recombinant human ESM-1
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产品特性
- Chromosomal location: 5q11.2
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纯化方法
- Protein A purified
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免疫原
- Recombinant human ESM-1 (ABIN1589766)
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亚型
- IgG
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anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibody
ESM1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6D4 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 51-150) antibodyESM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 22-184) antibodyESM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 WB 宿主: 小鼠 Monoclonal C7 unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 20-184) antibodyESM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 85-184) antibodyESM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Endothelial Cell-Specific Molecule 1 (ESM1) (AA 1-184) antibodyESM1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Western Blot: Use 1-5 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- 0.5X PBS, pH 7.2
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注意事项
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))
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别名
- Endocan/ESM-1
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背景
- Endocan, ESM1,Endocan, also known as endothelial cell specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNFα, IL1β, or lipopolysaccharide and downregulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte functionassociated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA1-mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
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基因ID
- 11082
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NCBI登录号
- NM_007036, NP_008967
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UniProt
- Q9NQ30
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途径
- Growth Factor Binding
抗原
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