KRIT1 抗体
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- 抗原 See all KRIT1 抗体
- KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KRIT1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- Recombinant human CCM1
- 产品特性
- Chromosomal location: 7q21.2
- 亚型
- IgG
- Top Product
- Discover our top product KRIT1 Primary Antibody
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anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 631-736) antibody
KRIT1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 471-585) antibodyKRIT1 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 637-736) antibodyKRIT1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D8 unconjugated
anti-KRIT1, Ankyrin Repeat Containing (KRIT1) (AA 1-736), (N-Term) antibodyKRIT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Western Blot: use 1-5 µg/mL
- 说明
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Rabbit IG Polyclonal Antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- 0.5X PBS, pH 7.2
- 注意事项
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- 有效期
- 6 months
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- 抗原
- KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
- 别名
- CCM-1 (KRIT1 产品)
- 别名
- CAM antibody, CCM1 antibody, 2010007K12Rik antibody, A630036P20Rik antibody, AA432855 antibody, AI450393 antibody, AI643869 antibody, BB155247 antibody, BB235701 antibody, Ccm1 antibody, RGD1305929 antibody, krit1 antibody, fb36f07 antibody, san antibody, santa antibody, wu:fb36f07 antibody, zgc:63585 antibody, KRIT1, ankyrin repeat containing antibody, KRIT1 antibody, Krit1 antibody, krit1 antibody
- 背景
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Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM-1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM-1 during the early steps of the CCM pathogenesis remain unknown. It was shown that CCM-1 represents an antiangiogenic protein to keep the human endothelium quiescent. CCM-1 inhibits endothelial proliferation, apoptosis, migration, lumen formation, and sprouting angiogenesis in primary human endothelial cells. CCM-1 strongly induces DLL4-NOTCH signaling, which promotes AKT phosphorylation but reduces phosphorylation of the mitogen-activated protein kinase ERK. Consistently, blocking of NOTCH activity alleviates CCM-1 effects. ERK phosphorylation is increased in human CCM lesions. Transplantation of CCM-1-silenced human endothelial cells into SCID mice recapitulates hallmarks of the CCM pathology and serves as a unique CCM model system.
Synonyms: CCM-1, Cerebral cavernous malformations protein 1, KRIT1, KRIT1, ankyrin repeat containing, CAM - 基因ID
- 3
- NCBI登录号
- NP_004903, NM_004912
- UniProt
- O00522
- 途径
- Cell RedoxHomeostasis
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