KDM5D 抗体
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- 抗原 See all KDM5D 抗体
- KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KDM5D antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- Recombinant human SMCY
- 产品特性
- Chromosomal location: Yq11, Yq11
- 亚型
- IgG
- Top Product
- Discover our top product KDM5D Primary Antibody
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- 应用备注
- Western Blot: use 1-5 µg/mL
- 说明
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Rabbit IG Polyclonal Antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Centrifuge vial prior to opening.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- 有效期
- 6 months
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- 抗原
- KDM5D (Lysine (K)-Specific Demethylase 5D (KDM5D))
- 别名
- SMCY/JARID1D (KDM5D 产品)
- 别名
- JARID1D antibody, Jarid1d antibody, DKFZp468I1010 antibody, HY antibody, HYA antibody, SMCY antibody, Smcy antibody, lysine demethylase 5D antibody, lysine (K)-specific demethylase 5D antibody, lysine demethylase 5C antibody, KDM5D antibody, Kdm5d antibody, KDM5C antibody
- 背景
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H-Y antigen is defined as a male histocompatibility antigen that causes rejection of male skin grafts by female recipients of the same inbred strain of rodents. Male-specific, or H-Y antigen(s), are also detected by cytotoxic T cells and antibodies. H-Y antigen appears to be an integral part of the membrane of most male cells. In addition, H-Y antibodies detect a soluble form of H-Y that is secreted by the testis. The gene (Smcy/SMCY) coding for H-Y antigen detected by T cells has been cloned. It is expressed ubiquitously in male mice and humans, and encodes an epitope that triggers a specific T-cell response in vitro. Additional epitopes coded for by different Y-chromosomal genes are probably required in vivo for the rejection of male grafts by female hosts. The molecular nature of H-Y antigen detected by antibodies on most male cells is not yet known. Testis-secreted, soluble H-Y antigen, however, was found to be identical to Müllerian-inhibiting substance (MIS). MIS cross-reacts with H-Y antibodies and identical findings were obtained for soluble H-Y antigen and MIS, i.e., secretion by testicular Sertoli and, to a lesser degree, ovarian cells, binding to a gonad-specific receptor, induction of gonadal sex reversal in vitro and, in cattle, in vivo. H-Y antisera also detect a molecule or molecules associated with the heterogametic sex in non-mammalian vertebrates. Molecular data on this antigen or antigens are not yet available.
Synonyms: KDM5D lysine (K)-specific demethylase 5D, HY, HYA - NCBI登录号
- NM_001146705, NP_001140177
- UniProt
- Q9BY66
- 途径
- Warburg Effect
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