PRAME 抗体 (AA 321-509)
Quick Overview for PRAME 抗体 (AA 321-509) (ABIN1589821)
抗原
See all PRAME 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 321-509
-
原理
- PRAME antibody
-
特异性
- Recombinant human PRAME (Met321-Asn509)
-
免疫原
- Recombinant human PRAME (Met321-Asn509)
-
亚型
- IgG
-
-
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 416-502) antibody
PRAME 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 151-250) antibodyPRAME 适用: 人, 小鼠 ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-509) antibodyPRAME 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 476-502), (C-Term) antibodyPRAME 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18763 unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 71-120) antibodyPRAME 适用: 人, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 460-510) antibodyPRAME 适用: 人, Cow, 马, 猴, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (N-Term) antibodyPRAME 适用: 人, 大鼠, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Preferentially Expressed Antigen in Melanoma (PRAME) (AA 1-200) antibodyPRAME 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Western Blot: Use 1-5 μg/mL
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
-
缓冲液
- PBS
-
注意事项
- Centrifuge vial prior to opening.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
-
有效期
- 24 months
-
-
- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
-
别名
- PRAME
-
背景
- Melanoma antigen preferentially expressed in tumors, Opa-interacting protein 4, MAPE, OIP4,PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumors. The physiological functions of PRAME in normal and tumor cells are unknown, although a role in the regulation of retinoic acid signaling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the Leucine-rich repeat (LRR) family of proteins, which have diverse functions. PRAME, or ""preferentially expressed antigen in melanoma"", was originally identified as a gene encoding a HLA-A24 restricted antigenic peptide presented to autologous tumor-specific cytotoxic T lymphocytes derived from a patient with melanoma. PRAME is synonymous with MAPE (melanoma antigen preferentially expressed in tumors) and OIP4 (OPA-interacting protein 4), and its expression profile defines it as a cancer-testis antigen. Cancer-testis antigens (CTAs) are encoded by non-mutated genes expressed at high levels in germinal tissues and tumors, but which are absent from or detected at low levels in other tissues. PRAME may be somewhat different to other cancer-testis antigens in that it shows some expression in normal tissues such as ovary, adrenal, placenta and endometrium. The C-terminus of human PRAME (amino acids 453-509) was also identified to bind Neisseria gonorrhoeae opacity factors, in this case the OPA-P protein. Thus PRAME is also known as OIP4 (OPA interacting protein),
-
基因ID
- 23532
-
NCBI登录号
- NM_006115, NP_006106
-
UniProt
- P78395
-
途径
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
抗原
-
