SAG 抗体
Quick Overview for SAG 抗体 (ABIN1580413)
抗原
See all SAG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- affinity purified antibody
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亚型
- IgG1
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anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 1-405) antibody
SAG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 4-249) antibodySAG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) antibodySAG 适用: 人, 大鼠, Cow, Pig WB, ICC, IF, IHC (fro) 宿主: 小鼠 Monoclonal PDS-1 unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (Internal Region) antibodySAG 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 369-418) antibodySAG 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 273-307) antibodySAG 适用: 小鼠 WB 宿主: 兔 Polyclonal RB53546 unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) antibodySAG 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 1-405) antibodySAG 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (AA 369-418), (pSer412) antibodySAG 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-S-Antigen, Retina and Pineal Gland (Arrestin) (SAG) (Internal Region) antibodySAG 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Try at dilutions of ~1:1,000 for immunofluorescence. For western blots try at 1:5,000. A suitable control tissue is retinal homogenate. The arrestin protein runs at about ~48 kDa on SDS-PAGE gels.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4°C short term or -20°C long term.
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- SAG (S-Antigen, Retina and Pineal Gland (Arrestin) (SAG))
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别名
- Arrestin-1/ S-antigen
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背景
- The arrestin proteins are a family of regulators of cell signaling of G protein-coupled receptors (GPCR). Visual arrestin was first discovered as a result of the experimental model of human uveitis, an autoimmune disease of the eye. In this model, called experimental allergic uveitis, animals were injected with extracts made from the retina of the same species mixed with Freund's complete adjuvant. The animals mounted a strong immune response to the extract, and the antibody response was used to identify several immunogenic retinal proteins. One of these was called S-antigen, for soluble antigen. The protein was found to be abundant in retina, about 48 kDa in molecular weight, and localized in the outer segments of the photoreceptors. Several years later, Hermann K�hn and colleagues discovered that this protein binds to phosphorylated rhodopsin and prevents this protein from activating transducin. Transducin is a typical heterotrimeric G protein, composed of alpha, and beta,gamma, subunits. Rhodopsin phosphorylation is mediated by Rhodopsin kinase (a.k.a. GRK1), the prototypic member of a family of GPCR kinases. Since the S-antigen protein arrested the activity of rhodopsin it was renamed arrestin, and became the prototypic member of the arrestin protein family. Subsequently, Robert
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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