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beta Amyloid 抗体

This anti-beta Amyloid antibody is a 小鼠 单克隆 antibody detecting beta Amyloid in WB, IHC, IF 和 ICC. Suitable for 人.
产品编号 ABIN1580412
发货至: 中国

Quick Overview for beta Amyloid 抗体 (ABIN1580412)

抗原

See all beta Amyloid (Abeta) 抗体
beta Amyloid (Abeta) (Amyloid beta (Abeta))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This beta Amyloid antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

AB9
  • 纯化方法

    affinity purified antibody

    亚型

    IgG2a
  • 应用备注

    The antibody solution can be used at dilutions of 1:1,000 or higher in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:1,000-2,000.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at 4°C short term or -20°C long term.
  • 抗原

    beta Amyloid (Abeta) (Amyloid beta (Abeta))

    背景

    Alzheimer's disease (AD) is a serious and common age related dementia which is characterized by the formation of senile plaques and neurofibrillary tangles. Senile plaques are extracellular accumulations of insoluble proteins found in cortical regions. A major component of senile plaques is beta,-amyloid, a.k.a. Abeta, a peptide predominantly of 42 or 40 amino acids. The Abeta, peptide is derived from a section of the membrane spanning domain and the immediate extracellular region of a much larger protein called the amyloid precursor protein (APP). This is an abundant protein of poorly understood function. The Abeta, peptides are generated by the activity of proteases called secretases, specifically the beta, and gamma, secretases. Certain mutations in the APP gene are associated with familial forms of AD, as are mutations in the genes encoding proteins forming the secretase enzymes, in line with the hypothesis that Abeta, accumulation is central to the AD disease process. Our antibody recognizes amino acids 1-16 of the Abeta, peptide and works well on western blots, on formalin fixed sections and as a capture reagent in ELISA. It was originally developed in the Mayo Clinic in Jacksonville in the laboratory of Dr. Todd Golde.

    途径

    Inflammasome
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