B-Cell Linker 抗体 (AA 150-178)
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北京 101111
Quick Overview for B-Cell Linker 抗体 (AA 150-178) (ABIN1539928)
抗原
See all B-Cell Linker (BLNK) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 150-178
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纯化方法
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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免疫原
- This BLNK antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human BLNK.
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亚型
- IgM
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应用备注
- WB: 1:500~8000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- BLNK Antibody(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
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有效期
- 6 months
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- B-Cell Linker (BLNK)
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别名
- BLNK
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背景
- This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
- 50466
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基因ID
- 29760
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NCBI登录号
- NP_001107566, NP_001245369, NP_037446
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UniProt
- Q8WV28
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途径
- BCR Signaling
抗原
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