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Cullin 2 抗体 (N-Term)

This anti-Cullin 2 antibody is a 兔 多克隆 antibody detecting Cullin 2 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN1539078
发货至: 中国

Quick Overview for Cullin 2 抗体 (N-Term) (ABIN1539078)

抗原

See all Cullin 2 (CUL2) 抗体
Cullin 2 (CUL2)

适用

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人, 小鼠

宿主

  • 70
  • 2
  • 1

克隆类型

  • 62
  • 11
多克隆

标记

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This Cullin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB33843
  • 抗原表位

    • 15
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    • 1
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    AA 150-179, N-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CUL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the N-terminal region of human CUL2.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    CUL2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

    有效期

    6 months
  • 抗原

    Cullin 2 (CUL2)

    别名

    CUL2

    背景

    Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

    分子量

    86983

    基因ID

    8453

    NCBI登录号

    NP_001185706, NP_001185707, NP_001185708, NP_003582

    UniProt

    Q13617

    途径

    M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome
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