STK4 抗体 (C-Term)
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Quick Overview for STK4 抗体 (C-Term) (ABIN1537341)
抗原
See all STK4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 443-470, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Stk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-470 amino acids from the C-terminal region of mouse Stk4.
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亚型
- Ig Fraction
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anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibody
STK4 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 303-487) antibodySTK4 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 1-39) antibodySTK4 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D7-8A10 unconjugated
anti-serine/threonine Kinase 4 (STK4) (C-Term) antibodyKO Validated STK4 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 391-485) antibodySTK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodySTK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) antibodyKD Validated STK4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB90 unconjugated Recombinant Antibody
anti-serine/threonine Kinase 4 (STK4) (AA 385-415) antibodySTK4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (AA 6-24) antibodySTK4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 4 (STK4) (pThr183) antibodySTK4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Mouse Stk4 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
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有效期
- 6 months
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- STK4 (serine/threonine Kinase 4 (STK4))
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别名
- Stk4
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背景
- Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
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分子量
- 55541
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基因ID
- 58231
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NCBI登录号
- NP_067395
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UniProt
- Q9JI11
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途径
- Tube Formation
抗原
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