ACER1 抗体 (C-Term)
Quick Overview for ACER1 抗体 (C-Term) (ABIN1536908)
抗原
See all ACER1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 236-263, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.
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亚型
- Ig Fraction
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anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibody
ACER1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibodyACER1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) antibodyACER1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (AA 141-190) antibodyACER1 适用: 人, 猴, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (C-Term) antibodyACER1 适用: 人, 大鼠, Cow, 豚鼠, 兔, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) antibodyACER1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- ACER1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
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有效期
- 6 months
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- ACER1 (Alkaline Ceramidase 1 (ACER1))
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别名
- ACER1
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背景
- Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).
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分子量
- 31095
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基因ID
- 125981
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NCBI登录号
- NP_597999
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UniProt
- Q8TDN7
抗原
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