ITGA6 抗体 (Cleaved-Glu942)
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北京 101111
Quick Overview for ITGA6 抗体 (Cleaved-Glu942) (ABIN1536134)
抗原
See all ITGA6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 923-972, Cleaved-Glu942
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原理
- Cleaved-Integrin α6 LC (E942) Antibody
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特异性
- Cleaved-Integrin α6 LC (E942) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α6 LC protein resulting from cleavage adjacent to E942.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- ITGA6 (Integrin, alpha 6 (ITGA6))
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别名
- ITGA6
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背景
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Synonyms: ITGA6, Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD antigen CD49f
Background: integrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Gene Name: ITGA6
Protein Name: Integrin alpha-6
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分子量
- 28 kDa
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基因ID
- 3655
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OMIM
- 147556
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UniProt
- P23229
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途径
- CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex
抗原
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